About the report
The Alzheimer’s risk report gives information on the genetic predisposition to Alzheimer’s disease based on APOE gene variants e2, e3 and e4. Out of these the e4 variant is known to be the strongest known genetic risk factor for Alzheimer’s disease. Though having these gene variants does not necessarily mean one would develop Alzheimer’s. At the same time, developing the condition can not be completely ruled out for people without the risk variants.
You can take this information with you on your next routine visit to your physician and understand your genetic risk for Alzheimer’s disease.
23andMe data analysis for Alzheimer’s disease
Alzheimer’s disease is a progressive neurodegenerative disorder that causes the gradual loss of nerve cells in the brain. This leads to dementia and decline in the ability to think and reason. For those of you who are looking for a quick knowledge about your APOE gene variants, you can use your raw data from 23andMe, Ancestry DNA or Family Tree DNA to get this information. You can then take this report on your next routine appointment with your physician get help to interpret them for you.
What to do if you have the risk variant
First off, having the risk APOE variant, e4 does not necessarily mean the individual will develop the disease. At the same time absence of the variant does not rule out the possibility of developing the condition.
Secondly, this report does not serve any diagnostic purpose. In the event that you find out that you have the e4 variant of the APOE gene, do not panic! Consult with a health care specialist who will help you interpret your reports.
It is also advisable to consult a genetic counselor. Genetic counselors help people understand genetic disorders and genetic test results.
The APOE gene encodes apolipoprotein E. It is a cholesterol carrier that is found in the brain and a few other organs. Though the exact role of this protein in the development of Alzheimer’s disease is unclear, several studies have shown it’s influence on the accumulation of amyloid beta protein. This ultimately leads to Alzheimer’s.
Important note: Your report may not contain all of the traits listed here depending upon the number of markers present in your raw data file.