Gene: ACOT11

Alternate names for this Gene: BFIT|STARD14|THEA|THEM1

Gene Summary: This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants.

Gene is located in Chromosome: 1

Location in Chromosome : 1p32.3

Description of this Gene: acyl-CoA thioesterase 11

Type of Gene: protein-coding

rs10736390 in ACOT11 gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs17110757 in ACOT11 gene and Central Nervous System Neoplasms PMID 19578366 2009 Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.

rs17110757 in ACOT11 gene and Glioma PMID 19578366 2009 Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.

rs11809810 in ACOT11 gene and Triglycerides measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.