Gene: ADAP2

Alternate names for this Gene: CENTA2|HSA272195|cent-b

Gene Summary: The protein encoded by this gene binds beta-tubulin and increases the stability of microtubules. The encoded protein can also translocate to the cell membrane and bind phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4). In addition, this protein is a GTPase-activating protein for ADP ribosylation factor 6 and may be able to block the entry of some RNA viruses.

Gene is located in Chromosome: 17

Location in Chromosome : 17q11.2

Description of this Gene: ArfGAP with dual PH domains 2

Type of Gene: protein-coding

rs35958868 in ADAP2 gene and Body Height PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 18391951 2008 Many sequence variants affecting diversity of adult human height.

PMID 25282103 2014 Defining the role of common variation in the genomic and biological architecture of adult human height.

rs7208859 in ADAP2 gene and Finding of Mean Corpuscular Hemoglobin PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs3760318 in ADAP2 gene and Height PMID 18391951 2008 Many sequence variants affecting diversity of adult human height.

rs7208859 in ADAP2 gene and Mean Corpuscular Volume (result) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs7225461 in ADAP2 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs3760318 in ADAP2 gene and Smoking PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs3760318 in ADAP2 gene and Smoking Behaviors PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.