Gene: AKT3

Alternate names for this Gene: MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2

Gene Summary: The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.

Gene is located in Chromosome: 1

Location in Chromosome : 1q43-q44

Description of this Gene: AKT serine/threonine kinase 3

Type of Gene: protein-coding

Gene: SDCCAG8

Alternate names for this Gene: BBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAP

Gene Summary: This gene encodes a centrosome associated protein. This protein may be involved in organizing the centrosome during interphase and mitosis. Mutations in this gene are associated with retinal-renal ciliopathy.

Gene is located in Chromosome: 1

Location in Chromosome : 1q43-q44

Description of this Gene: SHH signaling and ciliogenesis regulator SDCCAG8

Type of Gene: protein-coding

rs34770086 in AKT3;SDCCAG8 gene and Body Height PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 31564439 2019 Harmonizing Genetic Ancestry and Self-identified Race/Ethnicity in Genome-wide Association Studies.

rs14403 in AKT3;SDCCAG8 gene and Schizophrenia PMID 29483656 2018 Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.

PMID 23974872 2013 Genome-wide association analysis identifies 13 new risk loci for schizophrenia.

PMID 30285260 2019 Genome-Wide Association Study Detected Novel Susceptibility Genes for Schizophrenia and Shared Trans-Populations/Diseases Genetic Effect.

rs12093576 in AKT3;SDCCAG8 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.