Gene: APEH

Alternate names for this Gene: AARE|ACPH|APH|D3F15S2|D3S48E|DNF15S2|OPH

Gene Summary: This gene encodes the enzyme acylpeptide hydrolase, which catalyzes the hydrolysis of the terminal acetylated amino acid preferentially from small acetylated peptides. The acetyl amino acid formed by this hydrolase is further processed to acetate and a free amino acid by an aminoacylase. This gene is located within the same region of chromosome 3 (3p21) as the aminoacylase gene, and deletions at this locus are also associated with a decrease in aminoacylase activity. The acylpeptide hydrolase is a homotetrameric protein of 300 kDa with each subunit consisting of 732 amino acid residues. It can play an important role in destroying oxidatively damaged proteins in living cells. Deletions of this gene locus are found in various types of carcinomas, including small cell lung carcinoma and renal cell carcinoma.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: acylaminoacyl-peptide hydrolase

Type of Gene: protein-coding

Gene: MST1

Alternate names for this Gene: D3F15S2|DNF15S2|HGFL|MSP|NF15S2

Gene Summary: The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: macrophage stimulating 1

Type of Gene: protein-coding