Gene: APOL1

Alternate names for this Gene: APO-L|APOL|APOL-I|FSGS4

Gene Summary: This gene encodes a secreted high density lipoprotein which binds to apolipoprotein A-I. Apolipoprotein A-I is a relatively abundant plasma protein and is the major apoprotein of HDL. It is involved in the formation of most cholesteryl esters in plasma and also promotes efflux of cholesterol from cells. This apolipoprotein L family member may play a role in lipid exchange and transport throughout the body, as well as in reverse cholesterol transport from peripheral cells to the liver. Several different transcript variants encoding different isoforms have been found for this gene.

Gene is located in Chromosome: 22

Location in Chromosome : 22q12.3

Description of this Gene: apolipoprotein L1

Type of Gene: protein-coding

rs28480494 in APOL1 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs136161 in APOL1 gene and Diabetic Nephropathy PMID 26305897 2015 Genome-Wide Association and Trans-ethnic Meta-Analysis for Advanced Diabetic Kidney Disease: Family Investigation of Nephropathy and Diabetes (FIND).

rs1428826948 in APOL1 gene and FOCAL SEGMENTAL GLOMERULOSCLEROSIS 4, SUSCEPTIBILITY TO PMID 20647424 2010 Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

PMID 24206458 2013 APOL1 risk variants, race, and progression of chronic kidney disease.

rs2239785 in APOL1 gene and Focal glomerulosclerosis PMID 20668430 2010 A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.

rs2239785 in APOL1 gene and Glomerulonephritis PMID 20668430 2010 A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.

rs2239785 in APOL1 gene and Glomerulosclerosis (disorder) PMID 20668430 2010 A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.

rs73885319 in APOL1 gene and Kidney Failure, Chronic PMID 31178898 2019 Several variants at the <i>APOL1</i> locus were associated with ESKD including the <i>APOL1</i> G1 rs73885319 (<i>p</i> = 1.2 × 10<sup>-9</sup>).

rs1428826948 in APOL1 gene and Proteinuria PMID 20647424 2010 Association of trypanolytic ApoL1 variants with kidney disease in African Americans.

rs1428826948 in APOL1 gene and Vitamin D Deficiency PMID 20647424 2010 Association of trypanolytic ApoL1 variants with kidney disease in African Americans.