Gene: ARHGAP32

Alternate names for this Gene: GC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAP

Gene Summary: RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008].

Gene is located in Chromosome: 11

Location in Chromosome : 11q24.3

Description of this Gene: Rho GTPase activating protein 32

Type of Gene: protein-coding

rs525988 in ARHGAP32 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs371331393 in ARHGAP32 gene and Intracranial Aneurysm PMID 30823506 2019 The rs371331393 SNP, with a stop-gain function of <i>ARHGAP32</i> (11q24.3), showed the most significant association with the risk of IA (OR = 43.57, 95% CI: 21.84⁻86.95; <i>p</i> = 9.3 × 10<sup>-27</sup>).