Gene: ARIH2

Alternate names for this Gene: ARI2|TRIAD1

Gene Summary: The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet.

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: ariadne RBR E3 ubiquitin protein ligase 2

Type of Gene: protein-coding

rs11353326 in ARIH2 gene and Blood basophil count (lab test) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs11353326 in ARIH2 gene and Eosinophil count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs55786114 in ARIH2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.