Gene: BCL2L11

Alternate names for this Gene: BAM|BIM|BOD

Gene Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified.

Gene is located in Chromosome: 2

Location in Chromosome : 2q13

Description of this Gene: BCL2 like 11

Type of Gene: protein-coding

Gene: MIR4435-2HG

Alternate names for this Gene: AGD2|LINC00978|MIR4435-1HG|MORRBID|lncRNA-AWPPH

Gene Summary:

Gene is located in Chromosome: 2

Location in Chromosome : 2q13

Description of this Gene: MIR4435-2 host gene

Type of Gene: ncRNA