Gene: BCL9

Alternate names for this Gene: LGS

Gene Summary: BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies.

Gene is located in Chromosome: 1

Location in Chromosome : 1q21.2

Description of this Gene: BCL9 transcription coactivator

Type of Gene: protein-coding

rs6695965 in BCL9 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs79128089 in BCL9 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 28736931 2018 Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.

rs583583 in BCL9 gene and Schizophrenia PMID 23382809 2013 Especially we detected five SNPs in the first two genes/loci strongly associated with negative symptoms of schizophrenia (P(meta-analysis)<6.22×10(-6)), which included three SNPs in the BCL9 gene: rs583583 showed the strongest association at a P(meta-analysis) of 6.00×10(-7) and two SNPs in the C9orf5 (the top SNP is rs643410 with a p = 1.29 ×10(-6)).

rs11240089 in BCL9 gene and White Blood Cell Count procedure PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

rs594206 in BCL9 gene and response to cyclophosphamide PMID 24025145 2013 A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.