Gene: C8orf34

Alternate names for this Gene: VEST-1|VEST1

Gene Summary: This gene encodes a protein that is related to the cyclic AMP dependent protein kinase regulators. Naturally occurring mutations in this gene are associated with an increased risk for severe toxicities, such as diarrhea and neutropenia, in patients undergoing chemotherapeutic treatment.

Gene is located in Chromosome: 8

Location in Chromosome : 8q13.2

Description of this Gene: chromosome 8 open reading frame 34

Type of Gene: protein-coding

rs7825271 in C8orf34 gene and Aspartate aminotransferase measurement PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs2953950 in C8orf34 gene and Malignant Neoplasms PMID 29299148 2017 Cancer risk susceptibility loci in a Swedish population.

rs17478857 in C8orf34 gene and Narcolepsy PMID 19629137 2009 Genome-wide association database developed in the Japanese Integrated Database Project.

rs7825271 in C8orf34 gene and Polysomnography PMID 23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

rs17387279 in C8orf34 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs12543555 in C8orf34 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.