Gene: CARS1

Alternate names for this Gene: CARS|CYSRS|MCDDBH|MDBH|MGC:11246

Gene Summary: This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.4

Description of this Gene: cysteinyl-tRNA synthetase 1

Type of Gene: protein-coding

rs116487956 in CARS1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7481584 in CARS1 gene and Calcium level result PMID 24068962 2013 Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.

rs7481584 in CARS1 gene and Calcium measurement PMID 24068962 2013 Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.

rs739401 in CARS1 gene and Longevity PMID 20834067 2010 Joint influence of small-effect genetic variants on human longevity.