Gene: CD55

Alternate names for this Gene: CHAPLE|CR|CROM|DAF|TC

Gene Summary: This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins.

Gene is located in Chromosome: 1

Location in Chromosome : 1q32.2

Description of this Gene: CD55 molecule (Cromer blood group)

Type of Gene: protein-coding

rs12023811 in CD55 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs1114167430 in CD55 gene and COMPLEMENT HYPERACTIVATION, ANGIOPATHIC THROMBOSIS, AND PROTEIN-LOSING ENTEROPATHY PMID 28657861 2017 Loss of CD55 in Eculizumab-Responsive Protein-Losing Enteropathy.