Gene: CDC14A

Alternate names for this Gene: DFNB105|DFNB32|DFNB35|cdc14|hCDC14

Gene Summary: The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.

Gene is located in Chromosome: 1

Location in Chromosome : 1p21.2

Description of this Gene: cell division cycle 14A

Type of Gene: protein-coding

rs17420882 in CDC14A gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs148737918 in CDC14A gene and DEAFNESS, AUTOSOMAL RECESSIVE 32 PMID 29293958 2018 CDC14A phosphatase is essential for hearing and male fertility in mouse and human.

PMID 27259055 2016 Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause Autosomal-Recessive Severe to Profound Deafness.