Gene: CLEC1B

Alternate names for this Gene: 1810061I13Rik|CLEC2|CLEC2B|PRO1384|QDED721

Gene Summary: Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011].

Gene is located in Chromosome: 12

Location in Chromosome : 12p13.31-p13.2

Description of this Gene: C-type lectin domain family 1 member B

Type of Gene: protein-coding

Gene: CLEC12A

Alternate names for this Gene: CD371|CLL-1|CLL1|DCAL-2|MICL

Gene Summary: This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13.

Gene is located in Chromosome: 12

Location in Chromosome : 12p13.31

Description of this Gene: C-type lectin domain family 12 member A

Type of Gene: protein-coding