Gene: CNTN5

Alternate names for this Gene: HNB-2s|NB-2

Gene Summary: The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. This protein is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene is located in Chromosome: 11

Location in Chromosome : 11q22.1

Description of this Gene: contactin 5

Type of Gene: protein-coding

rs7927466 in CNTN5 gene and Arthritis, Gouty PMID 31289104 2019 Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.

rs1461677 in CNTN5 gene and Blood Protein Measurement PMID 31320639 2019 Genome and epigenome wide studies of neurological protein biomarkers in the Lothian Birth Cohort 1936.

PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs11223581 in CNTN5 gene and Cytokine Measurement PMID 22610502 2012 Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.

rs7927466 in CNTN5 gene and Gout PMID 31289104 2019 Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout.

rs61475845 in CNTN5 gene and Kynurenine Measurement PMID 29317604 2018 Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics.

rs1690818 in CNTN5 gene and Major Depressive Disorder PMID 27089181 2016 Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

PMID 29942085 2018 Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.

PMID 29317604 2018 Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics.

rs1939697 in CNTN5 gene and Primary biliary cirrhosis PMID 23000144 2012 Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.

rs67885470 in CNTN5 gene and Systolic Pressure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1690818 in CNTN5 gene and Unipolar Depression PMID 27089181 2016 Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.

rs1394461 in CNTN5 gene and Waist-Hip Ratio PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.

rs10893002 in CNTN5 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.