Gene: COLEC10

Alternate names for this Gene: 3MC3|CL-34|CLL1

Gene Summary: This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins.

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.12

Description of this Gene: collectin subfamily member 10

Type of Gene: protein-coding

rs10086835 in COLEC10 gene and Bone Density PMID 19801982 2009 Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.

PMID 29304378 2018 Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

PMID 19079262 2009 New sequence variants associated with bone mineral density.

PMID 22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

PMID 23437003 2013 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.

PMID 24945404 2014 Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.

PMID 24249740 2014 Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

PMID 18445777 2008 Multiple genetic loci for bone mineral density and fractures.

rs2062377 in COLEC10 gene and Bone Mineral Density Test PMID 24249740 2014 Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

PMID 22504420 2012 Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.

PMID 23437003 2013 Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.

rs2450083 in COLEC10 gene and Childhood asthma PMID 30929738 2019 Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.

rs12679857 in COLEC10 gene and Diabetes Mellitus, Insulin-Dependent PMID 21980299 2011 A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.

rs12681644 in COLEC10 gene and Eosinophil count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs773764995 in COLEC10 gene and Malpuech facial clefting syndrome PMID 28301481 2017 COLEC10 is mutated in 3MC patients and regulates early craniofacial development.

rs2062375 in COLEC10 gene and Osteoporosis PMID 20548944 2010 An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.

rs2465404 in COLEC10 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.