Gene: COLEC12

Alternate names for this Gene: CLP1|NSR2|SCARA4|SRCL

Gene Summary: This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. This protein is a scavenger receptor that displays several functions associated with host defense. It can bind to carbohydrate antigens on microorganisms, facilitating their recognition and removal. It also mediates the recognition, internalization, and degradation of oxidatively modified low density lipoprotein by vascular endothelial cells.

Gene is located in Chromosome: 18

Location in Chromosome : 18p11.32

Description of this Gene: collectin subfamily member 12

Type of Gene: protein-coding

rs2846667 in COLEC12 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs505110 in COLEC12 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs16944558 in COLEC12 gene and Metabolic Syndrome X PMID 29212154 2017 Additionally, we found that an interaction between the <i>APOA5</i> rs662799 and <i>COLEC12</i> rs16944558 SNPs influenced MetS, high triglyceride, and low HDL.