Gene: CTTNBP2

Alternate names for this Gene: C7orf8|CORTBP2|Orf4

Gene Summary: This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.

Gene is located in Chromosome: 7

Location in Chromosome : 7q31.31

Description of this Gene: cortactin binding protein 2

Type of Gene: protein-coding

rs13239186 in CTTNBP2 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 30054458 2018 Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.

rs757278 in CTTNBP2 gene and Juvenile arthritis PMID 24709693 2014 Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.

rs7807677 in CTTNBP2 gene and Major Depressive Disorder PMID 30718901 2019 Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.

rs6965740 in CTTNBP2 gene and Smoking PMID 30643258 2019 Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.