Gene: DCPS

Alternate names for this Gene: ARS|DCS1|HINT-5|HINT5|HSL1|HSPC015

Gene Summary: This gene encodes a member of the histidine triad family of pyrophosphatases that removes short mRNA fragments containing the 5' mRNA cap structure, which appear in the 3' -> 5' mRNA decay pathway, following deadenylation and exosome-mediated turnover. This enzyme hydrolyzes the triphosphate linkage of the cap structure (7-methylguanosine nucleoside triphosphate) to yield 7-methylguanosine monophosphate and nucleoside diphosphate. It protects the cell from the potentially toxic accumulation of these short, capped mRNA fragments, and regulates the activity of other cap-binding proteins, which are inhibited by their accumulation. It also acts as a transcript-specific modulator of pre-mRNA splicing and microRNA turnover.

Gene is located in Chromosome: 11

Location in Chromosome : 11q24.2

Description of this Gene: decapping enzyme, scavenger

Type of Gene: protein-coding