Gene: DENND2B

Alternate names for this Gene: HTS1|ST5|p126

Gene Summary: This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.

Gene is located in Chromosome: 11

Location in Chromosome : 11p15.4

Description of this Gene: DENN domain containing 2B

Type of Gene: protein-coding

Gene: LOC102724784

Alternate names for this Gene:

Gene Summary:

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rs4579928 in DENND2B;LOC102724784 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11042078 in DENND2B;LOC102724784 gene and Corpuscular Hemoglobin Concentration Mean PMID 23222517 2012 Seventy-five genetic loci influencing the human red blood cell.