Gene: DLEU2

Alternate names for this Gene: ALT1|BCMSUN|DLB2|LEU2|LINC00022|MIR15AHG|NCRNA00022|RFP2|RFP2OS|TRIM13OS

Gene Summary: This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1.

Gene is located in Chromosome: 13

Location in Chromosome : 13q14.2

Description of this Gene: deleted in lymphocytic leukemia 2

Type of Gene: ncRNA

rs9596219 in DLEU2 gene and Body Height PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

rs12583637 in DLEU2 gene and Diastolic blood pressure PMID 30224653 2018 Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

rs9596219 in DLEU2 gene and Height PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

rs749307626 in DLEU2 gene and Lipoprotein (a) measurement PMID 30108283 2018 A study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure.