Gene: DNAH17

Alternate names for this Gene: DNAHL1|DNEL2|SPGF39

Gene Summary: Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. DNAH17 is a heavy chain associated with axonemal dynein (Milisav and Affara, 1998 [PubMed 9545504]).[supplied by OMIM, Mar 2008]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000389840.7/ ENSP00000374490.6 RefSeq Select criteria :: based on manual assertion, conservation, expression ##RefSeq-Attributes-END##

Gene is located in Chromosome: 17

Location in Chromosome : 17q25.3

Description of this Gene: dynein axonemal heavy chain 17

Type of Gene: protein-coding

rs1515022 in DNAH17 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs72925845 in DNAH17 gene and Triglycerides measurement PMID 24886709 2014 Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.

rs2271613 in DNAH17 gene and Waist-Hip Ratio PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.