Gene: DNAL4

Alternate names for this Gene: MRMV3|PIG27

Gene Summary: This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella.

Gene is located in Chromosome: 22

Location in Chromosome : 22q13.1

Description of this Gene: dynein axonemal light chain 4

Type of Gene: protein-coding

Gene: SUN2

Alternate names for this Gene: UNC84B

Gene Summary: SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010].

Gene is located in Chromosome: 22

Location in Chromosome : 22q13.1

Description of this Gene: Sad1 and UNC84 domain containing 2

Type of Gene: protein-coding