Gene: DNM3

Alternate names for this Gene: Dyna III

Gene Summary: This gene encodes a member of a family of guanosine triphosphate (GTP)-binding proteins that associate with microtubules and are involved in vesicular transport. The encoded protein functions in the development of megakaryocytes. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 1

Location in Chromosome : 1q24.3

Description of this Gene: dynamin 3

Type of Gene: protein-coding

Gene: PIGC

Alternate names for this Gene: GPI2|GPIBD16|MRT62

Gene Summary: This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized.

Gene is located in Chromosome: 1

Location in Chromosome : 1q24.3

Description of this Gene: phosphatidylinositol glycan anchor biosynthesis class C

Type of Gene: protein-coding

rs17369123 in DNM3;PIGC gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs1011731 in DNM3;PIGC gene and Glomerular Filtration Rate PMID 31152163 2019 A catalog of genetic loci associated with kidney function from analyses of a million individuals.

rs1011731 in DNM3;PIGC gene and High density lipoprotein measurement PMID 29083408 2017 Exome-wide association study of plasma lipids in >300,000 individuals.

PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

rs714515 in DNM3;PIGC gene and Smoking PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs714515 in DNM3;PIGC gene and Smoking Behaviors PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs1011731 in DNM3;PIGC gene and Triglycerides measurement PMID 29083408 2017 Exome-wide association study of plasma lipids in >300,000 individuals.

PMID 29507422 2018 A large electronic-health-record-based genome-wide study of serum lipids.

rs1011731 in DNM3;PIGC gene and Waist-Hip Ratio PMID 20935629 2010 Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

PMID 25673412 2015 New genetic loci link adipose and insulin biology to body fat distribution.

PMID 30575882 2018 Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.