Gene: DOCK4

Alternate names for this Gene: -

Gene Summary: This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized.

Gene is located in Chromosome: 7

Location in Chromosome : 7q31.1

Description of this Gene: dedicator of cytokinesis 4

Type of Gene: protein-coding

rs17158930 in DOCK4 gene and Bipolar Disorder PMID 25944848 2015 Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.

rs10255299 in DOCK4 gene and C-reactive protein measurement PMID 22788528 2013 Genetic associations with C-reactive protein level and white blood cell count in the KARE study.

rs6951280 in DOCK4 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs17158930 in DOCK4 gene and Major Depressive Disorder PMID 25944848 2015 Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.

rs17158930 in DOCK4 gene and Schizophrenia PMID 25944848 2015 Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.

rs17158930 in DOCK4 gene and Unipolar Depression PMID 25944848 2015 Genome-wide association study identifies common variants associated with pharmacokinetics of psychotropic drugs.

rs10255299 in DOCK4 gene and White Blood Cell Count procedure PMID 22788528 2013 Genetic associations with C-reactive protein level and white blood cell count in the KARE study.

rs10428959 in DOCK4 gene and response to fenofibrate PMID 22890011 2012 Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.