Gene: FAM3C

Alternate names for this Gene: GS3786|ILEI

Gene Summary: This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells.

Gene is located in Chromosome: 7

Location in Chromosome : 7q31.31

Description of this Gene: FAM3 metabolism regulating signaling molecule C

Type of Gene: protein-coding

rs7776725 in FAM3C gene and Bone Density PMID 19396169 2009 On chromosome 7q31, rs7776725 (within the FAM3C gene) was associated with bone density at the radius (P = 1.0 x 10(-11)), tibia (P = 1.6 x 10(-6)) and heel (P = 1.9 x 10(-10)).

PMID 24945404 2014 Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.

PMID 29304378 2018 Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects.

PMID 22792070 2012 Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

PMID 28743860 2017 Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.

rs2254595 in FAM3C gene and Bone Mineral Density Test PMID 22792070 2012 Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.

PMID 24249740 2014 Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.

rs917727 in FAM3C gene and Lean body mass PMID 28743860 2017 Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus.

rs7776725 in FAM3C gene and Waist-Hip Ratio PMID 19396169 2009 A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.