Gene: FBXW12

Alternate names for this Gene: FBW12|FBXO12|FBXO35

Gene Summary: Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].

Gene is located in Chromosome: 3

Location in Chromosome : 3p21.31

Description of this Gene: F-box and WD repeat domain containing 12

Type of Gene: protein-coding

rs73831575 in FBXW12 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.