Gene: FEZ1

Alternate names for this Gene: UNC-76

Gene Summary: This gene is an ortholog of the C. elegans unc-76 gene, which is necessary for normal axonal bundling and elongation within axon bundles. Expression of this gene in C. elegans unc-76 mutants can restore to the mutants partial locomotion and axonal fasciculation, suggesting that it also functions in axonal outgrowth. The N-terminal half of the gene product is highly acidic. Alternatively spliced transcript variants encoding different isoforms of this protein have been described.

Gene is located in Chromosome: 11

Location in Chromosome : 11q24.2

Description of this Gene: fasciculation and elongation protein zeta 1

Type of Gene: protein-coding

rs11512640 in FEZ1 gene and Peripheral Arterial Diseases PMID 27082954 2016 Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease.

rs11220082 in FEZ1 gene and Schizophrenia PMID 22688191 2012 Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.

PMID 21926974 2011 Genome-wide association study identifies five new schizophrenia loci.

rs669052 in FEZ1 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.