Gene: FNIP1

Alternate names for this Gene: -

Gene Summary: This gene encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin.

Gene is located in Chromosome: 5

Location in Chromosome : 5q31.1

Description of this Gene: folliculin interacting protein 1

Type of Gene: protein-coding

rs758324 in FNIP1 gene and Alzheimer's Disease PMID 25778476 2016 A novel Alzheimer disease locus located near the gene encoding tau protein.

rs185120612 in FNIP1 gene and Blood basophil count (lab test) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs79577858 in FNIP1 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs185120612 in FNIP1 gene and Eosinophil count procedure PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs26008 in FNIP1 gene and Triglycerides measurement PMID 29083408 2017 Exome-wide association study of plasma lipids in >300,000 individuals.

rs593767 in FNIP1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.