Gene: FOSL2

Alternate names for this Gene: FRA2

Gene Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

Gene is located in Chromosome: 2

Location in Chromosome : 2p23.2

Description of this Gene: FOS like 2, AP-1 transcription factor subunit

Type of Gene: protein-coding

rs7562 in FOSL2 gene and Allergic Reaction PMID 29679657 2019 Eleven loci with new reproducible genetic associations with allergic disease risk.

rs4666070 in FOSL2 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs7606480 in FOSL2 gene and Eczema PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2279990 in FOSL2 gene and Inflammatory Bowel Diseases PMID 26192919 2015 Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

rs2048240 in FOSL2 gene and Systolic Pressure PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

PMID 28135244 2017 Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.