Gene: FOXN3

Alternate names for this Gene: C14orf116|CHES1|PRO1635

Gene Summary: This gene is a member of the forkhead/winged helix transcription factor family. Checkpoints are eukaryotic DNA damage-inducible cell cycle arrests at G1 and G2. Checkpoint suppressor 1 suppresses multiple yeast checkpoint mutations including mec1, rad9, rad53 and dun1 by activating a MEC1-independent checkpoint pathway. Alternative splicing is observed at the locus, resulting in distinct isoforms.

Gene is located in Chromosome: 14

Location in Chromosome : 14q31.3-q32.11

Description of this Gene: forkhead box N3

Type of Gene: protein-coding

rs8004664 in FOXN3 gene and Fasting blood glucose measurement PMID 22581228 2012 A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.

PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs8020333 in FOXN3 gene and Fasting blood sugar result PMID 22885924 2012 Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.

rs4904523 in FOXN3 gene and Intelligence PMID 29326435 2019 A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence.

PMID 29844566 2018 Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.

rs10484021 in FOXN3 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs4899973 in FOXN3 gene and Pseudotumor Cerebri PMID 29608535 2019 Genetic Survey of Adult-Onset Idiopathic Intracranial Hypertension.

rs3783853 in FOXN3 gene and Schizophrenia PMID 21926974 2011 Genome-wide association study identifies five new schizophrenia loci.

rs4904523 in FOXN3 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.