Gene: GABRB1

Alternate names for this Gene: DEE45|EIEE45

Gene Summary: The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding alpha 4, alpha 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.

Gene is located in Chromosome: 4

Location in Chromosome : 4p12

Description of this Gene: gamma-aminobutyric acid type A receptor subunit beta1

Type of Gene: protein-coding

rs148121703 in GABRB1 gene and Acute Coronary Syndrome PMID 28753643 2017 Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.

rs4396968 in GABRB1 gene and Cervix carcinoma PMID 28806749 2017 Defining the genetic susceptibility to cervical neoplasia-A genome-wide association study.

rs148121703 in GABRB1 gene and Coronary heart disease PMID 28753643 2017 Pharmacogenetic meta-analysis of baseline risk factors, pharmacodynamic, efficacy and tolerability endpoints from two large global cardiovascular outcomes trials for darapladib.

rs1159315 in GABRB1 gene and Polycystic Ovary Syndrome PMID 30343302 2019 High Genetic Risk Scores of ASIC2, MACROD2, CHRM3, and C2orf83 Genetic Variants Associated with Polycystic Ovary Syndrome Impair Insulin Sensitivity and Interact with Energy Intake in Korean Women.

rs12108623 in GABRB1 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.