Gene: GIGYF2

Alternate names for this Gene: GYF2|PARK11|PERQ2|PERQ3|TNRC15

Gene Summary: This gene contains CAG trinucleotide repeats and encodes a protein containing several stretches of polyglutamine residues. The encoded protein may be involved in the regulation of tyrosine kinase receptor signaling. This gene is located in a chromosomal region that was genetically linked to Parkinson disease type 11, and mutations in this gene were thought to be causative for this disease. However, more recent studies in different populations have been unable to replicate this association. Alternative splicing results in multiple transcript variants.

Gene is located in Chromosome: 2

Location in Chromosome : 2q37.1

Description of this Gene: GRB10 interacting GYF protein 2

Type of Gene: protein-coding

rs79928194 in GIGYF2 gene and Anxiety Disorders PMID 31116379 2019 Genetic Variants Associated With Anxiety and Stress-Related Disorders: A Genome-Wide Association Study and Mouse-Model Study.

rs283477 in GIGYF2 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs6704768 in GIGYF2 gene and Child Development Disorders, Pervasive PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

rs6704768 in GIGYF2 gene and Intelligence PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

rs769022021 in GIGYF2 gene and PARKINSON DISEASE 11, AUTOSOMAL DOMINANT, SUSCEPTIBILITY TO PMID 18358451 2008 Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease.

PMID 20060621 2011 Mutational screening and zebrafish functional analysis of GIGYF2 as a Parkinson-disease gene.

PMID 26134514 2015 GIGYF2 mutation in late-onset Parkinson's disease with cognitive impairment.

PMID 20178831 2010 Novel GIGYF2 gene variants in patients with Parkinson's disease in Chinese population.

rs4144797 in GIGYF2 gene and Schizophrenia PMID 29483656 2018 Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection.

PMID 25056061 2014 Biological insights from 108 schizophrenia-associated genetic loci.

PMID 31374203 2019 Pleiotropic Meta-Analysis of Cognition, Education, and Schizophrenia Differentiates Roles of Early Neurodevelopmental and Adult Synaptic Pathways.

PMID 28540026 2017 Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia.

rs6704768 in GIGYF2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.