Gene: GPD2

Alternate names for this Gene: GDH2|GPDM|mGDH|mGPDH

Gene Summary: The protein encoded by this gene localizes to the inner mitochondrial membrane and catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate, using FAD as a cofactor. Along with GDP1, the encoded protein constitutes the glycerol phosphate shuttle, which reoxidizes NADH formed during glycolysis. Two transcript variants encoding the same protein have been found for this gene.

Gene is located in Chromosome: 2

Location in Chromosome : 2q24.1

Description of this Gene: glycerol-3-phosphate dehydrogenase 2

Type of Gene: protein-coding

rs7561404 in GPD2 gene and Body Height PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs297578 in GPD2 gene and Intelligence PMID 29942086 2018 Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence.

rs56051278 in GPD2 gene and Motion Sickness PMID 25628336 2015 Genetic variants associated with motion sickness point to roles for inner ear development, neurological processes and glucose homeostasis.

rs297589 in GPD2 gene and Myopia PMID 27182965 2016 Detection and interpretation of shared genetic influences on 42 human traits.