Gene: GRIA4

Alternate names for this Gene: GLUR4|GLUR4C|GLURD|GluA4|NEDSGA

Gene Summary: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing of this gene results in transcript variants encoding different isoforms, which may vary in their signal transduction properties. Some haplotypes of this gene show a positive association with schizophrenia.

Gene is located in Chromosome: 11

Location in Chromosome : 11q22.3

Description of this Gene: glutamate ionotropic receptor AMPA type subunit 4

Type of Gene: protein-coding

Gene: RNU6-277P

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