Gene: GSDMC

Alternate names for this Gene: MLZE

Gene Summary:

Gene is located in Chromosome: 8

Location in Chromosome : 8q24.21

Description of this Gene: gasdermin C

Type of Gene: protein-coding

rs7833174 in GSDMC gene and Back Pain PMID 30261039 2018 Genome-wide meta-analysis of 158,000 individuals of European ancestry identifies three loci associated with chronic back pain.

rs4733727 in GSDMC gene and Body Fat Distribution PMID 30664634 2019 Genome-wide association study of body fat distribution identifies adiposity loci and sex-specific genetic effects.

rs2062078 in GSDMC gene and Body Height PMID 25429064 2015 Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 28552196 2017 Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

PMID 25282103 2014 Defining the role of common variation in the genomic and biological architecture of adult human height.

PMID 31562340 2019 Characterizing rare and low-frequency height-associated variants in the Japanese population.

PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs6470764 in GSDMC gene and Height PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

rs6470764 in GSDMC gene and Infant length PMID 25281659 2015 A novel common variant in DCST2 is associated with length in early life and height in adulthood.

rs4733725 in GSDMC gene and Lean body mass PMID 30593698 2019 Genomics of body fat percentage may contribute to sex bias in anorexia nervosa.

rs4733724 in GSDMC gene and Osteoarthritis of hip PMID 30374069 2018 Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis.

PMID 30664745 2019 Identification of new therapeutic targets for osteoarthritis through genome-wide analyses of UK Biobank data.

rs6651255 in GSDMC gene and Prolapsed lumbar disc PMID 28223688 2017 In light of presented findings, we speculate that the effect of rs6651255 on LDHsurg is driven by susceptibility to developing severe and persistent sciatica upon LDH.

rs6470765 in GSDMC gene and Smoking PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs6470765 in GSDMC gene and Smoking Behaviors PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.