Gene: HHIP-AS1

Alternate names for this Gene: -

Gene Summary:

Gene is located in Chromosome: 4

Location in Chromosome : 4q31.21

Description of this Gene: HHIP antisense RNA 1

Type of Gene: ncRNA

Gene: HHIP

Alternate names for this Gene: HIP

Gene Summary: This gene encodes a member of the hedgehog-interacting protein (HHIP) family. The hedgehog (HH) proteins are evolutionarily conserved protein, which are important morphogens for a wide range of developmental processes, including anteroposterior patterns of limbs and regulation of left-right asymmetry in embryonic development. Multiple cell-surface receptors are responsible for transducing and/or regulating HH signals. The HHIP encoded by this gene is a highly conserved, vertebrate-specific inhibitor of HH signaling. It interacts with all three HH family members, SHH, IHH and DHH. Two single nucleotide polymorphisms (SNPs) near this gene are significantly associated with risk of chronic obstructive pulmonary disease (COPD). A single nucleotide polymorphism in this gene is also strongly associated with human height.

Gene is located in Chromosome: 4

Location in Chromosome : 4q31.21

Description of this Gene: hedgehog interacting protein

Type of Gene: protein-coding

rs1812175 in HHIP-AS1;HHIP gene and Body Height PMID 18391951 2008 Many sequence variants affecting diversity of adult human height.

PMID 25282103 2014 Defining the role of common variation in the genomic and biological architecture of adult human height.

PMID 20397748 2010 Genome-wide association study of height and body mass index in Australian twin families.

PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.

PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

rs1812175 in HHIP-AS1;HHIP gene and Height PMID 18391951 2008 Many sequence variants affecting diversity of adult human height.

PMID 20397748 2010 Genome-wide association study of height and body mass index in Australian twin families.

PMID 23563607 2013 Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.

rs1812175 in HHIP-AS1;HHIP gene and Infant length PMID 25281659 2015 A novel common variant in DCST2 is associated with length in early life and height in adulthood.

rs1812175 in HHIP-AS1;HHIP gene and Physical Activity Measurement PMID 28448500 2017 Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults.

rs1812175 in HHIP-AS1;HHIP gene and Smoking PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.

rs1812175 in HHIP-AS1;HHIP gene and Smoking Behaviors PMID 28443625 2017 Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.