Gene: HNF4A

Alternate names for this Gene: FRTS4|HNF4|HNF4a7|HNF4a8|HNF4a9|HNF4alpha|MODY|MODY1|NR2A1|NR2A21|TCF|TCF14

Gene Summary: The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms.

Gene is located in Chromosome: 20

Location in Chromosome : 20q13.12

Description of this Gene: hepatocyte nuclear factor 4 alpha

Type of Gene: protein-coding

Gene: HNF4A-AS1

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Gene Summary:

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rs4812831 in HNF4A;HNF4A-AS1 gene and Diabetes Mellitus, Non-Insulin-Dependent PMID 21874001 2011 Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.