Gene: HOMER2

Alternate names for this Gene: ACPD|CPD|DFNA68|HOMER-2|VESL-2

Gene Summary: This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14.

Gene is located in Chromosome: 15

Location in Chromosome : 15q25.2

Description of this Gene: homer scaffold protein 2

Type of Gene: protein-coding

rs864309524 in HOMER2 gene and DEAFNESS, AUTOSOMAL DOMINANT 68 PMID 25816005 2015 HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice.

rs2046071 in HOMER2 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.

rs7182990 in HOMER2 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.