Gene: HPGDS

Alternate names for this Gene: GSTS|GSTS1|GSTS1-1|PGD2|PGDS

Gene Summary: Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes.

Gene is located in Chromosome: 4

Location in Chromosome : 4q22.3

Description of this Gene: hematopoietic prostaglandin D synthase

Type of Gene: protein-coding

rs7438414 in HPGDS gene and Age at menarche PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs11097414 in HPGDS gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs11938688 in HPGDS gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs11938688 in HPGDS gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs17021463 in HPGDS gene and Testicular Germ Cell Tumor PMID 23666239 2013 Meta-analysis identifies four new loci associated with testicular germ cell tumor.

PMID 28604732 2017 Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor.

PMID 28604728 2017 Identification of 19 new risk loci and potential regulatory mechanisms influencing susceptibility to testicular germ cell tumor.

rs17021463 in HPGDS gene and Testicular Neoplasms PMID 23666239 2013 Meta-analysis identifies four new loci associated with testicular germ cell tumor.