Gene: IL10RB

Alternate names for this Gene: CDW210B|CRF2-4|CRFB4|D21S58|D21S66|IL-10R2

Gene Summary: The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21.

Gene is located in Chromosome: 21

Location in Chromosome : 21q22.11

Description of this Gene: interleukin 10 receptor subunit beta

Type of Gene: protein-coding

rs2834167 in IL10RB gene and Blood Protein Measurement PMID 30072576 2018 Co-regulatory networks of human serum proteins link genetics to disease.

rs8134758 in IL10RB gene and High density lipoprotein measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.

rs1329427406 in IL10RB gene and INFLAMMATORY BOWEL DISEASE 25, AUTOSOMAL RECESSIVE PMID 27336593 2016 Large B-Cell Lymphoma in an Adolescent Patient With Interleukin-10 Receptor Deficiency and History of Infantile Inflammatory Bowel Disease.

PMID 22549091 2012 Loss of interleukin-10 signaling and infantile inflammatory bowel disease: implications for diagnosis and therapy.

rs8134758 in IL10RB gene and Serum HDL cholesterol measurement PMID 23063622 2012 Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.