Gene: IL1F10

Alternate names for this Gene: FIL1-theta|FKSG75|IL-1HY2|IL-38|IL1-theta|IL1HY2

Gene Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.

Gene is located in Chromosome: 2

Location in Chromosome : 2q14.1

Description of this Gene: interleukin 1 family member 10

Type of Gene: protein-coding

rs6761276 in IL1F10 gene and Blood Protein Measurement PMID 29875488 2018 Genomic atlas of the human plasma proteome.

rs6743376 in IL1F10 gene and C-reactive protein measurement PMID 24182552 2014 Novel gene variants predict serum levels of the cytokines IL-18 and IL-1ra in older adults.

rs13011842 in IL1F10 gene and Interleukin 1 Beta Measurement PMID 30206230 2018 GWAS for Interleukin-1β levels in gingival crevicular fluid identifies IL37 variants in periodontal inflammation.

rs6743376 in IL1F10 gene and Interleukin 1 Receptor Antagonist Measurement PMID 24182552 2014 Multiple SNPs were associated with these cytokines with genome-wide significance, including SNPs in the IL-18-BCO gene region of chromosome 2 for IL-18 (top SNP rs2250417, P=1.9×10(-32)) and in the IL-1 gene family region of chromosome 2 for IL-1ra (rs6743376, P=2.3×10(-26)).

rs10496448 in IL1F10 gene and Leukemia, Myelocytic, Acute PMID 27903959 2017 Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.