Gene: IL2RA

Alternate names for this Gene: CD25|IDDM10|IL2R|IMD41|TCGFR|p55

Gene Summary: The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. A cytokine profile that includes IL2R in plasma of patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been reported to be significantly elevated.

Gene is located in Chromosome: 10

Location in Chromosome : 10p15.1

Description of this Gene: interleukin 2 receptor subunit alpha

Type of Gene: protein-coding

Gene: LOC107984201

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