Gene: INTS2

Alternate names for this Gene: INT2|KIAA1287

Gene Summary: INTS2 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.127058.1, SRR1660807.130184.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

Gene is located in Chromosome: 17

Location in Chromosome : 17q23.2

Description of this Gene: integrator complex subunit 2

Type of Gene: protein-coding

rs12938171 in INTS2 gene and Malignant neoplasm of ovary PMID 21964575 2011 Mutations in BRIP1 confer high risk of ovarian cancer.

rs2014444 in INTS2 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.