Gene: IRAIN
Alternate names for this Gene:
Gene Summary:
Gene is located in Chromosome:
Location in Chromosome :
Description of this Gene:
Type of Gene:
Gene: IGF1R
Alternate names for this Gene: CD221|IGFIR|IGFR|JTK13
Gene Summary: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene is located in Chromosome: 15
Location in Chromosome : 15q26.3
Description of this Gene: insulin like growth factor 1 receptor
Type of Gene: protein-coding
rs7402982 in
IRAIN;IGF1R gene and
Birth Weight
PMID 27680694 2016 Genome-wide associations for birth weight and correlations with adult disease.
PMID 31043758 2019 Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors.
rs2871865 in
IRAIN;IGF1R gene and
Body Height
PMID 31217584 2019 Genetic analyses of diverse populations improves discovery for complex traits.
PMID 25429064 2015 Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.
rs2871865 in
IRAIN;IGF1R gene and
Height
PMID 20881960 2010 Hundreds of variants clustered in genomic loci and biological pathways affect human height.
PMID 21194676 2011 Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height.