Gene: KAT2B

Alternate names for this Gene: CAF|P/CAF|PCAF

Gene Summary: CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation.

Gene is located in Chromosome: 3

Location in Chromosome : 3p24.3

Description of this Gene: lysine acetyltransferase 2B

Type of Gene: protein-coding

rs9874923 in KAT2B gene and Alcohol consumption PMID 24376456 2013 Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.

rs12636078 in KAT2B gene and Finding of Mean Corpuscular Hemoglobin PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

rs12636078 in KAT2B gene and Mean Corpuscular Volume (result) PMID 27863252 2016 The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

PMID 29403010 2018 Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases.

rs9874923 in KAT2B gene and Mean blood pressure PMID 24376456 2013 Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.

rs12636078 in KAT2B gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4858758 in KAT2B gene and Systolic Pressure PMID 30578418 2019 Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

rs2623079 in KAT2B gene and White Blood Cell Count procedure PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs2948094 in KAT2B gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.