Gene: KCNC4

Alternate names for this Gene: C1orf30|HKSHIIIC|KSHIIIC|KV3.4

Gene Summary: The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene.

Gene is located in Chromosome: 1

Location in Chromosome : 1p13.3

Description of this Gene: potassium voltage-gated channel subfamily C member 4

Type of Gene: protein-coding

rs17358800 in KCNC4 gene and Malignant neoplasm of oropharynx PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs17358800 in KCNC4 gene and Malignant neoplasm of posterior wall of oropharynx PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs17358800 in KCNC4 gene and Oropharyngeal Carcinoma PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs17358800 in KCNC4 gene and Primary malignant neoplasm of lateral wall of oropharynx PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs12138917 in KCNC4 gene and Red Blood Cell Count measurement PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs17358800 in KCNC4 gene and malignant neoplasm of lateral wall of oropharynx PMID 27749845 2016 Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

rs76577427 in KCNC4 gene and mathematical ability PMID 30038396 2018 Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals.