Gene: KLRG1

Alternate names for this Gene: 2F1|CLEC15A|MAFA|MAFA-2F1|MAFA-L|MAFA-LIKE

Gene Summary: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor (KLR) family, which is a group of transmembrane proteins preferentially expressed in NK cells. Studies in mice suggested that the expression of this gene may be regulated by MHC class I molecules.

Gene is located in Chromosome: 12

Location in Chromosome : 12p13.31

Description of this Gene: killer cell lectin like receptor G1

Type of Gene: protein-coding

Gene: PZP

Alternate names for this Gene: CPAMD6

Gene Summary: The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients.

Gene is located in Chromosome: 12

Location in Chromosome : 12p13.31

Description of this Gene: PZP alpha-2-macroglobulin like

Type of Gene: protein-coding