Gene: LGR4

Alternate names for this Gene: BNMD17|GPR48

Gene Summary: The protein encoded by this gene is a G-protein coupled receptor that binds R-spondins and activates the Wnt signaling pathway. This Wnt signaling pathway activation is necessary for proper development of many organs of the body.

Gene is located in Chromosome: 11

Location in Chromosome : 11p14.1

Description of this Gene: leucine rich repeat containing G protein-coupled receptor 4

Type of Gene: protein-coding

rs78321654 in LGR4 gene and Alopecia PMID 28196072 2017 Genetic prediction of male pattern baldness.

rs58604758 in LGR4 gene and Hair Color PMID 30531825 2018 Genome-wide study of hair colour in UK Biobank explains most of the SNP heritability.

rs11030003 in LGR4 gene and Vital capacity PMID 30595370 2019 Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

rs4536164 in LGR4 gene and Waist-Hip Ratio PMID 30239722 2019 Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.